A 35-year-old woman presents with increasing headache, nausea, vertigo, decreasing vision in both eyes and persistent fever. She also complains of pain in her legs when she goes jogging. Her blood pressure is 190/ 110 mmHg and her femoral pulses are weak, with a radiofemoral delay.

What is the most likely diagnosis?

A 22-year-old college student complains of stiffness and low back pain that is worse in the mornings. An X-ray shows obliteration of the sacroiliac joints.

Given the likely clinical diagnosis, what would be the most appropriate treatment for him?

A 45-year-old orthodox Muslim woman is brought to the Rheumatology Clinic by her husband. On questioning, she complains of pain in most of her joints associated with difficulty in walking and raising her arms. Blood tests show a 

microcytic hypochromic anaemia with: total calcium 2.04 mmol/1. phosphate 0.35 mmol/1, alkaline phosphatase 546 IU/1. total bilirubin 11 μmol/l. aspartate aminotransferase (AST) 25 IU/l. alanine aminotransferase (ALT) 16 IU/1. albumin 30 g/l. X-rays of the limbs show Looser's zones in

the inferior femoral neck on the left side and the right medial femoral shaft.

What is the most likely diagnosis?

A 20-year-old man presents wit h a 4-day history of high spiking pyrexia and arthralgia. On examination he has a maculopapular. salmon-pink rash on his trunk and arms and his distal interphalangeal joints are swollen. Hepatosplenomegaly is present.

What is the most likely diagnosis?